Efficacy of Modafinil on Fatigue and Excessive Daytime Sleepiness

Efficacy of Modafinil on Fatigue and Excessive Daytime Sleepiness

This meta-analysis was aimed to assess drug safety and effects of modafinil on fatigue and EDS associated with neurological disorders.

• Title: Efficacy of Modafinil on Fatigue and Excessive Daytime Sleepiness Associated with Neurological Disorders: A Systematic Review and Meta-Analysis
• Authors: Ping Sheng, Lijun Hou, Xiang Wang, Xiaowen Wang, Chengguang Huang, Mingkun Yu, Xi Han, and Yan Dong
• Date: 2013
• Source: PLoS One. 2013; 8(12): e81802. doi:  10.1371/journal.pone.0081802

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Efficacy of Modafinil on Fatigue and Excessive Daytime Sleepiness

Lofexidine and Autism

Lofexidine and Autism

Lofexidine was modestly effective in the short-term treatment of irritability in some children with autistic disorder.

• Title: Psychopharmacological Treatment Of Autistic Disorders: Lofexidine As An Useful Alternative
• Authors: Helmut Niederhofer, W Staffen, A Mair
• Date: 2003
• Source: Priory Lodge Education Ltd 

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Lofexidine and Autism

GABApentin in SSRI-refractory panic disorder

GABApentin in SSRI-refractory panic disorder

GABApentin, when combined with SSRI, demonstrated significant effects in reducing panic and anxiety symptoms.

• Title: GABApentin Treatment Response In Selective Serotonin Reuptake Inhibitor (SSRI)-Refractory Panic Disorder
• Authors: Dr. Simon Chiu
• Date: 2005
• Source: Priory Lodge Education Ltd 

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GABApentin in SSRI-refractory panic disorder

Anxiety, Depression and Patient Adherence

Anxiety, Depression and Patient Adherence 

This article presents a quantitative review and synthesis of studies correlating treatment noncompliance with anxiety and depression. Compared with nondepressed patients, the odds are 3 times greater that depressed patients will be noncompliant with medical treatment recommendations. The results point to the importance of recognizing depression as a risk factor for poor outcomes among patients who might not be adhering to medical advice.

• Title: Depression Is a Risk Factor for Noncompliance With Medical Treatment - Meta-analysis of the Effects of Anxiety and Depression on Patient Adherence 
• Authors: M. Robin DiMatteo, PhD; Heidi S. Lepper, PhD; Thomas W. Croghan, MD
• Date: 2000
• Source: Arch Intern Med. 2000;160(14):2101-2107. doi:10.1001/archinte.160.14.2101.

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Anxiety, Depression and Patient Adherence

Clozapine vs Classical Antipsychotics on Treating Schizophrenia

Clozapine vs Classical Antipsychotics on Treating Schizophrenia

This paper describes a state-of-the-art approach of SPECT to correlate neuropsychological evaluation.

• Title: CLOZAPINE VERSUS CLASSICAL ANTIPSYCHOTICS ON TREATING SCHIZOPHRENIA; USING SPECT AND PANSS
• Authors: Sharafi M, M.D. 
• Date: n/a
• Source: Priory Lodge Education Ltd 

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Clozapine vs Classical Antipsychotics on Treating Schizophrenia

CBT and Pharmacotherapy for Insomnia

CBT and Pharmacotherapy for Insomnia

Insomnia, defined as difficulty initiating or maintaining sleep with impaired daytime functioning attributed to poor sleep, is one of the most common complaints brought to a physician's office practice. The objective of this study was to evaluate the clinical efficacy of behavioral and pharmacological therapy.

• Title: Cognitive Behavior Therapy and Pharmacotherapy for Insomnia - A Randomized Controlled Trial and Direct Comparison 
• Authors: Gregg D. Jacobs, PhD; Edward F. Pace-Schott, MA; Robert Stickgold, PhD; Michael W. Otto, PhD
• Date: 2004
• Source: Arch Intern Med. 2004;164(17):1888-1896. doi:10.1001/archinte.164.17.1888.

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CBT and Pharmacotherapy for Insomnia